Billing & Coding for BELVIQ® and BELVIQ XR®

Here we provide general billing and coding information for BELVIQ® and BELVIQ XR®. Please check with the payor to verify coding or special billing requirements. Correct coding is the responsibility of the provider submitting a claim for the item or service.

National Drug Codes help providers and payors identify specific product package sizes.
The NDCs for BELVIQ® and BELVIQ XR® are listed below.

Package Size for BELVIQ®


Bottle of 60


Package Size for BELVIQ XR®


Bottle of 30


Some payors require providers to report 11-digit NDCs when reporting a drug on a claim form. Converting the 10-digit NDC for BELVIQ® to an 11-digit NDC requires the use of a leading zero in the product code section of the NDC (i.e., the middle section):

10-Digit NDC for BELVIQ®

11-Digit NDC with Leading Zero for BELVIQ®



10-Digit NDC for BELVIQ XR®

11-Digit NDC with Leading Zero for BELVIQ XR®



ICD codes for primary diagnosis, secondary diagnoses and other weight-related comorbid conditions help providers and payors proceed with the benefit investigation and prior authorization process, if required.
The ICD-10 codes applicable for BELVIQ® and BELVIQ XR® use are listed below.

Primary Diagnosis

ICD-10 Code

Description of Diagnosis Code


Morbid (severe) obesity due to excess calories


Other obesity due to excess calories


Drug-induced obesity


Morbid (severe) obesity with alveolar hypoventilation including Pickwickian syndrome




Other obesity


Obesity, unspecified, NOS

*needs to be accompanied with a diagnosis for a weight-related comorbid condition (below)

Secondary Diagnoses (if applicable for specific insurer)

ICD-10 Code

Specific BMI

ICD-10 Code

Specific BMI


BMI 27.0 – 27.9**


BMI 36.0 – 36.9


BMI 28.0 – 28.9**


BMI 37.0 – 37.9


BMI 29.0 – 29.9**


BMI 38.0 – 38.9


BMI 30.0 – 30.9


BMI 39.0 – 39.9


BMI 31.0 – 31.9


BMI 40.0 – 44.9


BMI 32.0 – 32.9


BMI 45.0– 49.9


BMI 33.0 – 33.9


BMI 50 – 59.9


BMI 34.0 – 34.9


BMI 60.0 – 69.9


BMI 35.0 – 35.9


BMI 70 or greater

**need to be accompanied with a diagnosis for a weight-related comorbid condition (below)

Weight-Related Comorbid Condition(s) to Support Use of FDA-Approved Medication for Chronic Weight Management (if applicable for specific insurer)

ICD-10 Code

Description of Diagnosis Code


Type 2 Diabetes




Obstructive sleep apnea






Cardiovascular disease


Impaired fasting glucose

Do Your Patients Need Financial Assistance?

Programs run by Eisai and Assistance Foundations are available to manage out-of-pocket costs

Chronic Weight Management

BELVIQ® or BELVIQ XR® may help your patients lose weight

Eisai cannot guarantee payment of any claim. Coding, coverage, and reimbursement may vary significantly by payor, plan, patient, and setting of care. Actual coverage and reimbursement decisions are made by individual payors following the receipt of claims. For additional information, customers should consult with their payors for all relevant coding, reimbursement, and coverage requirements. It is the sole responsibility of the provider to select the proper code and ensure the accuracy of all claims used in seeking reimbursement. All services must be medically appropriate and properly supported in the patient medical record.

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BELVIQ®/BELVIQ XR® is indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) of 30 kg/m2 or greater (obese), or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e.g., hypertension, dyslipidemia, type 2 diabetes).

Limitations of Use

  • The safety and efficacy of coadministration of BELVIQ/BELVIQ XR with other products intended for weight loss, including prescription drugs (e.g., phentermine), over-the-counter drugs, and herbal preparations, have not been established.
  • The effect of BELVIQ/BELVIQ XR on cardiovascular morbidity and mortality has not been established.

Important Safety Information


  • Pregnancy: BELVIQ/BELVIQ XR should not be taken during pregnancy or by women who are planning to become pregnant.
  • Hypersensitivity: Patients with prior hypersensitivity reactions to lorcaserin or to any of the product components should not take BELVIQ/BELVIQ XR. Hypersensitivity reactions have been reported.

Warnings and Precautions

  • Serotonin Syndrome or Neuroleptic Malignant Syndrome (NMS)- like reactions: BELVIQ/BELVIQ XR is a serotonergic drug. The development of potentially life-threatening serotonin syndrome or Neuroleptic Malignant Syndrome (NMS)-like reactions have been reported during use of serotonergic drugs, including, but not limited to, selective serotonin-norepinephrine reuptake inhibitors, and selective serotonin reuptake inhibitors, tricyclic antidepressants, bupropion, triptans, dietary supplements such as St. John's Wort and tryptophan, drugs that impair metabolism of serotonin (including monoamine oxidase inhibitors), dextromethorphan, lithium, tramadol, antipsychotics or other dopamine antagonists, particularly when used in combination. Patients should be monitored for the emergence of serotonin syndrome symptoms or NMS-like reactions, including agitation, hallucinations, coma, tachycardia, labile blood pressure, hyperthermia, hyperreflexia, incoordination, nausea, vomiting, diarrhea, and muscle rigidity. Treatment with BELVIQ/BELVIQ XR and any concomitant serotonergic or antidopaminergic agents should be discontinued immediately if the above events occur and supportive symptomatic treatment should be initiated.
  • Valvular heart disease: Patients should not take BELVIQ/BELVIQ XR in combination with potent 5-HT2B receptor agonists that have been associated with regurgitant valvular heart disease (e.g., cabergoline). In clinical trials, 2.4% of patients taking BELVIQ and 2.0% of patients taking placebo developed valvular regurgitation: none of these patients were symptomatic. BELVIQ/BELVIQ XR should be used with caution in patients with congestive heart failure (CHF). Patients who develop signs and symptoms of valvular heart disease, including dyspnea, dependent edema, CHF, or a new cardiac murmur, should be evaluated and discontinuation of BELVIQ/BELVIQ XR should be considered.
  • Cognitive impairment: Impairment in attention, memory, somnolence, confusion, and fatigue have been reported in patients taking BELVIQ. Patients should not drive a car or operate heavy machinery until they know how BELVIQ/BELVIQ XR affects them.
  • Psychiatric disorders: The recommended daily dose should not be exceeded, as higher doses may cause euphoria, hallucination, and dissociation. Monitor patients for the development or worsening of depression, suicidal thoughts or behaviors, and/or any changes in mood. Discontinue BELVIQ/BELVIQ XR in patients who develop suicidal thoughts or behaviors.
  • Hypoglycemia: Weight loss may increase the risk of hypoglycemia in patients with type 2 diabetes mellitus who are being treated with antidiabetic medications, so measurement of blood sugar levels before and during treatment with BELVIQ/BELVIQ XR is recommended. Decreases in doses of antidiabetic medications or changes in medication regimen should be considered.
  • Priapism: Men who experience priapism should immediately discontinue BELVIQ/BELVIQ XR and seek emergency medical attention. BELVIQ/BELVIQ XR should be used with caution with erectile dysfunction medications. BELVIQ/BELVIQ XR should be used with caution in men who have conditions that might predispose them to priapism (e.g., sickle cell anemia, multiple myeloma, or leukemia), or in men with anatomical deformation of the penis (e.g., angulation, cavernosal fibrosis, or Peyronie's disease).
  • Heart rate decreases: Because BELVIQ/BELVIQ XR may cause a slow heartbeat, it should be used with caution in patients with a history of bradycardia or heart block greater than first degree.
  • Monitoring Considerations: Consider monitoring for CBC changes, signs and symptoms of prolactin excess, and pulmonary hypertension.

Most Common Adverse Reactions for BELVIQ®

  • In patients without diabetes: headache (17%), dizziness (9%), fatigue (7%), nausea (8%), dry mouth (5%), and constipation (6%).
  • In patients with diabetes: hypoglycemia (29%), headache (15%), back pain (12%), cough (8%), and fatigue (7%).

Most Common Adverse Reactions for BELVIQ XR®

  • Common side effects in patients on BELVIQ XR were similar to those seen in patients on BELVIQ.

Nursing Mothers

  • BELVIQ/BELVIQ XR should not be taken by women who are nursing.
BELVIQ®/BELVIQ XR® is a federally controlled substance (CIV) because they may be abused or lead to dependence.
For more information about BELVIQ®/BELVIQ XR® see full Prescribing Information

This information is intended for use by healthcare professionals in the United States only. Eisai Inc. recognizes the Internet is a global communications medium; however, laws, regulatory requirements, and medical practices for pharmaceutical products vary from country to country. The Prescribing Information included here is not appropriate for use outside the United States. This site contains information about products that may have different product labeling in different countries. This site is published by Eisai Inc.

BELVIQ® and BELVIQ XR® are registered trademarks of Eisai Inc.